منابع مشابه
Regulatory B-Cells in Transplantation
B-cells have been long accepted as the main cellular component in humoral responses. Their effector function is based on antibody and cytokine production. The development of donor-specific antibodies by B-cells has deleterious consequences in graft and patients survival. Recently, a new subset of IL-10-secreting B-cells with regulatory capacity in allergic and autoimmune diseases has been shown...
متن کاملNoncognate function of B cells in transplantation.
How B cells affect the outcome of transplants is a question of enduring interest. Initial efforts to answer that question suggested, wrongly, that B cells have no impact on transplantation. Now, however, B cells are known to influence not only the outcome of vascularized grafts through the production of anti-donor antibodies but also the competence of cellular immunity through a number of physi...
متن کاملB cells and transplantation: an educational resource.
Allogeneic hematopoietic cell transplantation (HCT) offers a unique opportunity to monitor the development of immune reconstitution using the patient as his or her own control. Furthermore, the donor serves as an HLA-identical normal control and source of adoptive immune transfer. Donor hematopoietic stem cells (HSCs) differentiate and proliferate to repopulate all blood lineages providing norm...
متن کاملB cells and kidney transplantation: beyond antibodies.
Despite advances in immunosuppression over the last three decades, long-termkidney transplant survival is suboptimal,1 and mechanisms of late graft injury are incompletely understood. There remains a need for identifying and validating biomarkers capable of accurately stratifying patients into those at high versus low risk for developing late kidney allograft failure. While donor-reactive effec...
متن کاملMelatonin improves spermatogonial stem cells transplantation efficiency in azoospermic mice
Objective(s):Transplantation quality improvement and reduction of cellular damage are important goals that are now considered by researchers. Melatonin is secreted from the pineal gland and some organs such as testes. According to beneficial effects of melatonin (such as its antioxidant and antiapoptotic properties), researchers have proposed that the use of melatonin may improve transplantatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2016
ISSN: 1053-2498
DOI: 10.1016/j.healun.2016.01.1232